Smoking Related Cancers and Loci at Chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish Population
Identifieur interne : 006036 ( Main/Exploration ); précédent : 006035; suivant : 006037Smoking Related Cancers and Loci at Chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish Population
Auteurs : Ewa Jaworowska [Pologne] ; Joanna Trubicka [Pologne] ; Marcin R. Lener [Pologne] ; Bartłomiej Masoj [Pologne] ; El Bieta Złowocka-Perłowska [Pologne] ; James D. Mckay [France] ; Hélène Renard [France] ; Dorota Oszutowska [Pologne] ; Dominika Wokołorczyk [Pologne] ; Jakub Lubi Ski [Pologne] ; Tomasz Grodzki [Pologne] ; Piotr Serwatowski [Pologne] ; Katarzyna Nej-Wołosiak [Pologne] ; Aleksandra Tołoczko-Grabarek [Pologne] ; Andrzej Sikorski [Pologne] ; Marcin Słojewski [Pologne] ; Anna Jakubowska [Pologne] ; Cezary Cybulski [Pologne] ; Jan Lubi Ski [Pologne] ; Rodney J. Scott [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Abstract
Genetic factors associated with the risk of smoking related cancers have until recently remained elusive. Since the publication of a genome-wide association study (GWAS) on lung cancer new genetic loci have been identified that appear to be associated with disease risk. In this replication study we genotyped 14 single nucleotide polymorphisms (SNPs) located at the 5p12.3-p15.33, 6p21.3-p22.1, 6q23-q27 and 15q25.1 loci in 874 lung, 450 bladder, 418 laryngeal cancer cases and cancer-free controls, matched by year of birth and sex to the cases. Our results revealed that loci in the chromosome region 15q25.1 (rs16969968[A], rs8034191[G]) and 5p15 (rs402710[T]) are associated with lung cancer risk in the Polish population (smoking status adjusted OR = 1.45, 1.35, 0.77; p≤0.0001, 0.0005, 0.002; 95%CI 1.23–1.72, 1.14–1.59, 0.66–0.91 respectively). None of the other regions analyzed herein were implicated in the risk of lung, bladder or laryngeal cancer. This study supports previous findings on lung cancer but fails to show association of SNPs located in 15q25.1 and 5p15 region with other smoking related cancers like bladder and laryngeal cancer.
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DOI: 10.1371/journal.pone.0025057
PubMed: 21966413
PubMed Central: 3178595
Affiliations:
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Mckay</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Oszutowska, Dorota" sort="Oszutowska, Dorota" uniqKey="Oszutowska D" first="Dorota" last="Oszutowska">Dorota Oszutowska</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Wokolorczyk, Dominika" sort="Wokolorczyk, Dominika" uniqKey="Wokolorczyk D" first="Dominika" last="Wokołorczyk">Dominika Wokołorczyk</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lubi Ski, Jakub" sort="Lubi Ski, Jakub" uniqKey="Lubi Ski J" first="Jakub" last="Lubi Ski">Jakub Lubi Ski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, 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Szczecin-Zdunowo</wicri:regionArea><wicri:noRegion>Szczecin-Zdunowo</wicri:noRegion></affiliation></author><author><name sortKey="Nej Wolosiak, Katarzyna" sort="Nej Wolosiak, Katarzyna" uniqKey="Nej Wolosiak K" first="Katarzyna" last="Nej-Wołosiak">Katarzyna Nej-Wołosiak</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Toloczko Grabarek, Aleksandra" sort="Toloczko Grabarek, Aleksandra" uniqKey="Toloczko Grabarek A" first="Aleksandra" last="Tołoczko-Grabarek">Aleksandra Tołoczko-Grabarek</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Sikorski, Andrzej" sort="Sikorski, Andrzej" uniqKey="Sikorski A" first="Andrzej" last="Sikorski">Andrzej Sikorski</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Slojewski, Marcin" sort="Slojewski, Marcin" uniqKey="Slojewski M" first="Marcin" last="Słojewski">Marcin Słojewski</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lubi Ski, Jan" sort="Lubi Ski, Jan" uniqKey="Lubi Ski J" first="Jan" last="Lubi Ski">Jan Lubi Ski</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Discipline of Medical Genetics, University of Newcastle and The Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Medical Genetics, University of Newcastle and The Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21966413</idno><idno type="pmc">3178595</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178595</idno><idno type="RBID">PMC:3178595</idno><idno type="doi">10.1371/journal.pone.0025057</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002C17</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C17</idno><idno type="wicri:Area/Pmc/Curation">002A67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A67</idno><idno type="wicri:Area/Pmc/Checkpoint">002167</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002167</idno><idno type="wicri:Area/Ncbi/Merge">000B83</idno><idno type="wicri:Area/Ncbi/Curation">000B83</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B83</idno><idno type="wicri:Area/Main/Merge">006369</idno><idno type="wicri:Area/Main/Curation">006036</idno><idno type="wicri:Area/Main/Exploration">006036</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Smoking Related Cancers and Loci at Chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish Population</title><author><name sortKey="Jaworowska, Ewa" sort="Jaworowska, Ewa" uniqKey="Jaworowska E" first="Ewa" last="Jaworowska">Ewa Jaworowska</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Trubicka, Joanna" sort="Trubicka, Joanna" uniqKey="Trubicka J" first="Joanna" last="Trubicka">Joanna Trubicka</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lener, Marcin R" sort="Lener, Marcin R" uniqKey="Lener M" first="Marcin R." last="Lener">Marcin R. Lener</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Masoj, Bartlomiej" sort="Masoj, Bartlomiej" uniqKey="Masoj B" first="Bartłomiej" last="Masoj">Bartłomiej Masoj</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Radiotherapy, Western Pomeranian Oncology Center, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Radiotherapy, Western Pomeranian Oncology Center, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Zlowocka Perlowska, El Bieta" sort="Zlowocka Perlowska, El Bieta" uniqKey="Zlowocka Perlowska E" first="El Bieta" last="Złowocka-Perłowska">El Bieta Złowocka-Perłowska</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Department of Genetic Epidemiology, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Oszutowska, Dorota" sort="Oszutowska, Dorota" uniqKey="Oszutowska D" first="Dorota" last="Oszutowska">Dorota Oszutowska</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Wokolorczyk, Dominika" sort="Wokolorczyk, Dominika" uniqKey="Wokolorczyk D" first="Dominika" last="Wokołorczyk">Dominika Wokołorczyk</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lubi Ski, Jakub" sort="Lubi Ski, Jakub" uniqKey="Lubi Ski J" first="Jakub" last="Lubi Ski">Jakub Lubi Ski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Grodzki, Tomasz" sort="Grodzki, Tomasz" uniqKey="Grodzki T" first="Tomasz" last="Grodzki">Tomasz Grodzki</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Regional Hospital for Lung Diseases, Szczecin-Zdunowo, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Regional Hospital for Lung Diseases, Szczecin-Zdunowo</wicri:regionArea><wicri:noRegion>Szczecin-Zdunowo</wicri:noRegion></affiliation></author><author><name sortKey="Serwatowski, Piotr" sort="Serwatowski, Piotr" uniqKey="Serwatowski P" first="Piotr" last="Serwatowski">Piotr Serwatowski</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Regional Hospital for Lung Diseases, Szczecin-Zdunowo, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Regional Hospital for Lung Diseases, Szczecin-Zdunowo</wicri:regionArea><wicri:noRegion>Szczecin-Zdunowo</wicri:noRegion></affiliation></author><author><name sortKey="Nej Wolosiak, Katarzyna" sort="Nej Wolosiak, Katarzyna" uniqKey="Nej Wolosiak K" first="Katarzyna" last="Nej-Wołosiak">Katarzyna Nej-Wołosiak</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Toloczko Grabarek, Aleksandra" sort="Toloczko Grabarek, Aleksandra" uniqKey="Toloczko Grabarek A" first="Aleksandra" last="Tołoczko-Grabarek">Aleksandra Tołoczko-Grabarek</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Sikorski, Andrzej" sort="Sikorski, Andrzej" uniqKey="Sikorski A" first="Andrzej" last="Sikorski">Andrzej Sikorski</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Slojewski, Marcin" sort="Slojewski, Marcin" uniqKey="Slojewski M" first="Marcin" last="Słojewski">Marcin Słojewski</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Urology and Urological Oncology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Lubi Ski, Jan" sort="Lubi Ski, Jan" uniqKey="Lubi Ski J" first="Jan" last="Lubi Ski">Jan Lubi Ski</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Discipline of Medical Genetics, University of Newcastle and The Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Medical Genetics, University of Newcastle and The Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genetic factors associated with the risk of smoking related cancers have until recently remained elusive. Since the publication of a genome-wide association study (GWAS) on lung cancer new genetic loci have been identified that appear to be associated with disease risk. In this replication study we genotyped 14 single nucleotide polymorphisms (SNPs) located at the 5p12.3-p15.33, 6p21.3-p22.1, 6q23-q27 and 15q25.1 loci in 874 lung, 450 bladder, 418 laryngeal cancer cases and cancer-free controls, matched by year of birth and sex to the cases. Our results revealed that loci in the chromosome region 15q25.1 (rs16969968[A], rs8034191[G]) and 5p15 (rs402710[T]) are associated with lung cancer risk in the Polish population (smoking status adjusted OR = 1.45, 1.35, 0.77; p≤0.0001, 0.0005, 0.002; 95%CI 1.23–1.72, 1.14–1.59, 0.66–0.91 respectively). None of the other regions analyzed herein were implicated in the risk of lung, bladder or laryngeal cancer. 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Rafnar</name></author><author><name sortKey="Sulem, P" uniqKey="Sulem P">P Sulem</name></author><author><name sortKey="Stacey, Sn" uniqKey="Stacey S">SN Stacey</name></author><author><name sortKey="Geller, F" uniqKey="Geller F">F Geller</name></author><author><name sortKey="Gudmundsson, J" uniqKey="Gudmundsson J">J Gudmundsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Sa" uniqKey="Miller S">SA Miller</name></author><author><name sortKey="Dykes, Dd" uniqKey="Dykes D">DD Dykes</name></author><author><name sortKey="Polesky, Hf" uniqKey="Polesky H">HF Polesky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherry, St" uniqKey="Sherry S">ST Sherry</name></author><author><name sortKey="Ward, M" uniqKey="Ward M">M Ward</name></author><author><name sortKey="Sirotkin, K" uniqKey="Sirotkin K">K Sirotkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barrett, Jc" uniqKey="Barrett J">JC Barrett</name></author><author><name sortKey="Fry, B" uniqKey="Fry B">B Fry</name></author><author><name sortKey="Maller, J" uniqKey="Maller J">J Maller</name></author><author><name sortKey="Daly, Mj" uniqKey="Daly M">MJ Daly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menashe, I" uniqKey="Menashe I">I Menashe</name></author><author><name sortKey="Rosenberg, Ps" uniqKey="Rosenberg P">PS Rosenberg</name></author><author><name sortKey="Chen, Be" uniqKey="Chen B">BE Chen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Pologne</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="Pologne"><noRegion><name sortKey="Jaworowska, Ewa" sort="Jaworowska, Ewa" uniqKey="Jaworowska E" first="Ewa" last="Jaworowska">Ewa Jaworowska</name></noRegion><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><name sortKey="Grodzki, Tomasz" sort="Grodzki, Tomasz" uniqKey="Grodzki T" first="Tomasz" last="Grodzki">Tomasz Grodzki</name><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><name sortKey="Lener, Marcin R" sort="Lener, Marcin R" uniqKey="Lener M" first="Marcin R." last="Lener">Marcin R. Lener</name><name sortKey="Lubi Ski, Jakub" sort="Lubi Ski, Jakub" uniqKey="Lubi Ski J" first="Jakub" last="Lubi Ski">Jakub Lubi Ski</name><name sortKey="Lubi Ski, Jan" sort="Lubi Ski, Jan" uniqKey="Lubi Ski J" first="Jan" last="Lubi Ski">Jan Lubi Ski</name><name sortKey="Masoj, Bartlomiej" sort="Masoj, Bartlomiej" uniqKey="Masoj B" first="Bartłomiej" last="Masoj">Bartłomiej Masoj</name><name sortKey="Masoj, Bartlomiej" sort="Masoj, Bartlomiej" uniqKey="Masoj B" first="Bartłomiej" last="Masoj">Bartłomiej Masoj</name><name sortKey="Nej Wolosiak, Katarzyna" sort="Nej Wolosiak, Katarzyna" uniqKey="Nej Wolosiak K" first="Katarzyna" last="Nej-Wołosiak">Katarzyna Nej-Wołosiak</name><name sortKey="Oszutowska, Dorota" sort="Oszutowska, Dorota" uniqKey="Oszutowska D" first="Dorota" last="Oszutowska">Dorota Oszutowska</name><name sortKey="Serwatowski, Piotr" sort="Serwatowski, Piotr" uniqKey="Serwatowski P" first="Piotr" last="Serwatowski">Piotr Serwatowski</name><name sortKey="Sikorski, Andrzej" sort="Sikorski, Andrzej" uniqKey="Sikorski A" first="Andrzej" last="Sikorski">Andrzej Sikorski</name><name sortKey="Slojewski, Marcin" sort="Slojewski, Marcin" uniqKey="Slojewski M" first="Marcin" last="Słojewski">Marcin Słojewski</name><name sortKey="Toloczko Grabarek, Aleksandra" sort="Toloczko Grabarek, Aleksandra" uniqKey="Toloczko Grabarek A" first="Aleksandra" last="Tołoczko-Grabarek">Aleksandra Tołoczko-Grabarek</name><name sortKey="Trubicka, Joanna" sort="Trubicka, Joanna" uniqKey="Trubicka J" first="Joanna" last="Trubicka">Joanna Trubicka</name><name sortKey="Wokolorczyk, Dominika" sort="Wokolorczyk, Dominika" uniqKey="Wokolorczyk D" first="Dominika" last="Wokołorczyk">Dominika Wokołorczyk</name><name sortKey="Zlowocka Perlowska, El Bieta" sort="Zlowocka Perlowska, El Bieta" uniqKey="Zlowocka Perlowska E" first="El Bieta" last="Złowocka-Perłowska">El Bieta Złowocka-Perłowska</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name></region><name sortKey="Renard, Helene" sort="Renard, Helene" uniqKey="Renard H" first="Hélène" last="Renard">Hélène Renard</name></country><country name="Australie"><noRegion><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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